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Comment
. 2003 Oct 3;302(5642):65-7.
doi: 10.1126/science.1091256.

Neuroscience. Stout guards of the central nervous system

R Mechoulam  1 , A H Lichtman
Affiliations
Comment

Neuroscience. Stout guards of the central nervous system

R Mechoulam et al. Science. .

Abstract

Endocannabinoids have paradoxical effects on the mammalian nervous system: Sometimes they block neuronal excitability and other times they augment it. In their Perspective, Mechoulam and Lichtman discuss new work (Marsicano et al.) showing that activation of the cannabinoid receptor CB1 by the endocannabinoid anandamide protects against excitotoxic damage in a mouse model of kainic acid-induced epilepsy.

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  • CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
    Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B. Marsicano G, et al. Science. 2003 Oct 3;302(5642):84-8. doi: 10.1126/science.1088208. Science. 2003. PMID: 14526074

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