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Clinical Trial
. 2003 Sep;189(3):799-802.
doi: 10.1067/s0002-9378(03)00765-8.

Duration of antibiotic therapy after preterm premature rupture of fetal membranes

Sally Y Segel  1 , Annette M Miles, Bonnie Clothier, Samuel Parry, George A Macones
Affiliations
Clinical Trial

Duration of antibiotic therapy after preterm premature rupture of fetal membranes

Sally Y Segel et al. Am J Obstet Gynecol. 2003 Sep.

Abstract

Objective: This study was undertaken to compare the efficacy of 3 days versus 7 days of ampicillin in prolonging gestation for at least 7 days in women with preterm premature rupture of membranes (PPROM).

Study design: We performed a randomized clinical trial comparing 3 days of ampicillin with 7 days ampicillin in patients with PPROM. Our primary outcome was the prolongation of pregnancy for at least 7 days. Secondary outcomes included rates of chorioamnionitis, postpartum endometritis, and neonatal morbidity and mortality.

Results: Forty-eight patients were randomly selected. There was no statistically significant difference in the ability to achieve a 7-day latency (relative risk 0.83, 95% CI 0.51-1.38). In addition, there was no statistically significant difference in the rates of chorioamnionitis, endometritis, and our composite neonatal morbidity.

Conclusion: In patients with PPROM, length of antibiotic therapy does not change the rate of a 7-day latency or affect the rate of chorioamnionitis, postpartum endometritis, or neonatal morbidity.

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