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Review
. 2003 Sep 25;40(1):2-4.
doi: 10.1016/s0896-6273(03)00602-0.

Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back

Bruce R Ransom  1 , Angus M Brown
Affiliations
Free article
Review

Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back

Bruce R Ransom et al. Neuron. .
Free article

Abstract

Ischemic injury of cells in the central nervous system is typically set in motion by influx of extracellular Ca(2+). In this issue of Neuron, Stys and colleagues propose that ischemic injury in spinal cord axons is partly the result of ryanodine receptor-mediated release of Ca(2+) from the endoplasmic reticulum (ER), a site of intracellular Ca(2+) storage.

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