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Review
. 2003 Oct;4(10):939-43.
doi: 10.1038/sj.embor.embor921.

The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins

Jan-Willem L de Gier  1 , Joen Luirink
Affiliations
Review

The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins

Jan-Willem L de Gier et al. EMBO Rep. 2003 Oct.

Abstract

In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly.

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Figures

Figure 1
Figure 1
Model of the roles that the ribosome and YidC might have in the targeting and insertion of membrane proteins in Escherichia coli. Two inner membrane protein (IMP) assembly pathways are known to exist in E. coli: (A) the YidC pathway and (C) the SRP–Sec translocon–YidC pathway. In addition, an SRP–YidC pathway (B) might be operational. The ribosome seems to have a key role in the targeting of at least SRP–Sec translocon–YidC-dependent IMPs. FtsY, SRP-receptor; L23, L23 component of the large subunit of the ribosome; L29, L29 component of the large subunit of the ribosome; RNC, ribosome nascent chain complex; SRP, signal recognition particle; TF, trigger factor.
None
Jan-Willem L. de Gier is the recipient of an EMBO Young Investigator Award
None
See this image and copyright information in PMC

References

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