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. 2003 Nov;35(3):217-8.
doi: 10.1038/ng1251. Epub 2003 Oct 5.

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

Erno Wienholds  1 , Marco J Koudijs, Freek J M van Eeden, Edwin Cuppen, Ronald H A Plasterk
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Free article

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

Erno Wienholds et al. Nat Genet. 2003 Nov.
Free article

Abstract

MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.

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