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. 2003 Nov;35(3):215-7.
doi: 10.1038/ng1253. Epub 2003 Oct 5.

Dicer is essential for mouse development

Emily Bernstein  1 , Sang Yong Kim, Michelle A Carmell, Elizabeth P Murchison, Heather Alcorn, Mamie Z Li, Alea A Mills, Stephen J Elledge, Kathryn V Anderson, Gregory J Hannon
Affiliations

Dicer is essential for mouse development

Emily Bernstein et al. Nat Genet. 2003 Nov.

Erratum in

  • Nat Genet. 2003 Nov;35(3):287

Abstract

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

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