Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Aug;69(8):750-6.
doi: 10.1055/s-2003-42780.

Cytotoxic saponins from Schefflera fagueti

Giuseppina Cioffi  1 , Alessandra Braca, Giuseppina Autore, Ivano Morelli, Aldo Pinto, Fabio Venturella, Nunziatina De Tommasi
Affiliations

Cytotoxic saponins from Schefflera fagueti

Giuseppina Cioffi et al. Planta Med. 2003 Aug.

Abstract

Six new lupane (1 - 4) and oleanane saponins (5 and 6) were isolated from the aerial parts of Schefflera fagueti Baill. (Araliaceae). Their structures were determined by 2D-NMR spectroscopy (DQF-COSY, 1D-TOCSY, 2D-HOHAHA, 1D-ROESY, HSQC, HMBC). The antiproliferative activity of compounds 1 - 6 and of their prosapogenins (1a - 6a) was evaluated using three continuous murine and human culture cell lines J774, HEK-293, WEHI-164. Oleanane saponins 5 and 6 were the most active, showing significant inhibitory effects on all cell lines, while their prosapogenins 5a and 6a demonstrated minor activity.

PubMed Disclaimer

MeSH terms