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. 2003 Oct 16;5(21):3959-61.
doi: 10.1021/ol0356643.

Cobalt-catalyzed three-component coupling reaction of alkyl halides, 1,3-dienes, and trimethylsilylmethylmagnesium chloride

Keiya Mizutani  1 , Hiroshi Shinokubo, Koichiro Oshima
Affiliations

Cobalt-catalyzed three-component coupling reaction of alkyl halides, 1,3-dienes, and trimethylsilylmethylmagnesium chloride

Keiya Mizutani et al. Org Lett. .

Abstract

[reaction: see text] A combination of CoCl(2) and 1,6-bis(diphenylphosphino)hexane catalyzes a novel three-component coupling reaction of alkyl bromides, 1,3-dienes, and silylmethylmagnesium chloride, yielding homoallylsilanes in good to excellent yields. The reaction involves a radical species from alkyl halides.

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