Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Dec 1;89(23):11126-30.
doi: 10.1073/pnas.89.23.11126.

Requirement for coenzyme Q in plasma membrane electron transport

I L Sun  1 , E E Sun, F L Crane, D J Morré, A Lindgren, H Löw
Affiliations

Requirement for coenzyme Q in plasma membrane electron transport

I L Sun et al. Proc Natl Acad Sci U S A. .

Abstract

Coenzyme Q is required in the electron transport system of rat hepatocyte and human erythrocyte plasma membranes. Extraction of coenzyme Q from the membrane decreases NADH dehydrogenase and NADH:oxygen oxidoreductase activity. Addition of coenzyme Q to the extracted membrane restores the activity. Partial restoration of activity is also found with alpha-tocopherylquinone, but not with vitamin K1. Analogs of coenzyme Q inhibit NADH dehydrogenase and oxidase activity and the inhibition is reversed by added coenzyme Q. Ferricyanide reduction by transmembrane electron transport from HeLa cells is inhibited by coenzyme Q analogs and restored with added coenzyme Q10. Reduction of external ferricyanide and diferric transferrin by HeLa cells is accompanied by proton release from the cells. Inhibition of the reduction by coenzyme Q analogs also inhibits the proton release, and coenzyme Q10 restores the proton release activity. Trans-plasma membrane electron transport stimulates growth of serum-deficient cells, and added coenzyme Q10 increases growth of HeLa (human adenocarcinoma) and BALB/3T3 (mouse fibroblast) cells. The evidence is consistent with a function for coenzyme Q in a trans-plasma membrane electron transport system which influences cell growth.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1987 Oct 8;926(1):70-8 - PubMed
    1. Arch Biochem Biophys. 1962 Mar;96:580-2 - PubMed
    1. Indian J Biochem. 1965 Jun;2(2):80-4 - PubMed
    1. J Am Chem Soc. 1968 Sep 11;90(19):5334-6 - PubMed
    1. J Bioenerg Biomembr. 1984 Dec;16(5-6):583-95 - PubMed

Publication types

LinkOut - more resources