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. 1992 Dec 1;89(23):11486-9.
doi: 10.1073/pnas.89.23.11486.

Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells

T Briese  1 , J C de la Torre, A Lewis, H Ludwig, W I Lipkin
Affiliations

Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells

T Briese et al. Proc Natl Acad Sci U S A. .

Abstract

Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

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