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. 2003 Nov 3;13(21):3817-20.
doi: 10.1016/j.bmcl.2003.07.012.

A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

Yujia Dai  1 , Yan Guo, Michael L Curtin, Junling Li, Lori J Pease, Jun Guo, Patrick A Marcotte, Keith B Glaser, Steven K Davidsen, Michael R Michaelides
Affiliations

A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

Yujia Dai et al. Bioorg Med Chem Lett. .

Abstract

A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human cancer cell lines.

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