Review
doi: 10.1016/0968-0004(92)90016-3.
Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin
Affiliations
- PMID: 1455513
- DOI: 10.1016/0968-0004(92)90016-3
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Review
Signal transduction and the actin cytoskeleton: the roles of MARCKS and profilin
Trends Biochem Sci.
1992 Oct.
Abstract
MARCKS and profilin, two actin-binding proteins, are discussed to illustrate the mechanism by which extracellular signals are coupled to changes in the structure of the actin cytoskeleton. MARCKS is a filamentous actin-crosslinking protein that appears to function as an integrator of protein kinase C and calcium (Ca2+)/calmodulin signals in the regulation of actin-membrane interactions. New data suggest that profilin is activated by the coordinated action of receptor tyrosine kinases and phospholipase C-gamma 1 to stimulate the stabilization of actin filaments.
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