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. 2003 Oct 22;125(42):12672-3.
doi: 10.1021/ja036972z.

Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts

Tomotaka Okino  1 , Yasutaka Hoashi, Yoshiji Takemoto
Affiliations

Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts

Tomotaka Okino et al. J Am Chem Soc. .

Abstract

Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).

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