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. 2003 Sep;21(7):773-6.
doi: 10.1016/s0730-725x(03)00178-4.

MRI of the lung gas-space at very low-field using hyperpolarized noble gases

Arvind K Venkatesh  1 , Adelaide X Zhang, Joey Mansour, Lyubov Kubatina, Chang Hyun Oh, Gregory Blasche, M Selim Unlü, Dilip Balamore, Ferenc A Jolesz, Bennett B Goldberg, Mitchell S Albert
Collaborators, Affiliations

MRI of the lung gas-space at very low-field using hyperpolarized noble gases

Arvind K Venkatesh et al. Magn Reson Imaging. 2003 Sep.

Abstract

In hyperpolarized (HP) noble-gas magnetic resonance imaging, large nuclear spin polarizations, about 100,000 times that ordinarily obtainable at thermal equilibrium, are created in 3He and 129Xe. The enhanced signal that results can be employed in high-resolution MRI studies of void spaces such as in the lungs. In HP gas MRI the signal-to-noise ratio (SNR) depends only weakly on the static magnetic field (B(0)), making very low-field (VLF) MRI possible; indeed, it is possible to contemplate portable MRI using light-weight solenoids or permanent magnets. This article reports the first in vivo VLF MR images of the lungs in humans and in rats, obtained at a field of only 15 millitesla (150 Gauss).

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