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. 2003 Oct 21;118(1-2):147-51.
doi: 10.1016/s0169-328x(03)00329-2.

Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Masaaki Arai  1 , Shigeru Amano, Akihide Ryo, Akiyuki Hada, Toru Wakatsuki, Masahiro Shuda, Nobuo Kondoh, Mikio Yamamoto
Affiliations

Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat

Masaaki Arai et al. Brain Res Mol Brain Res. .

Abstract

Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.

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