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. 1992 Sep;37(1-2):140-6.
doi: 10.1007/BF01987903.

Macrophage tumoricidal mechanisms are selectively altered by prenatal chlordane exposure

S A Theus  1 , D R Tabor, L S Soderberg, J B Barnett
Affiliations

Macrophage tumoricidal mechanisms are selectively altered by prenatal chlordane exposure

S A Theus et al. Agents Actions. 1992 Sep.

Abstract

Macrophages (m phi) derived from mice treated in utero with chlordane show a significant delay of tumoricidal induction activity. In this study, m phi from chlordane-treated animals required a 48 h in vitro period of induction with interferon-gamma and lipopolysaccharide (IFN/LPS) before they could kill P815 targets. Similarly, m phi from chlordane-treated animals also failed to produce an immediate H2O2 burst upon perturbation. Conversely, their stimulated control m phi counterparts were tumoricidal by 2 h and exhibited a respiratory burst without any delay. Moreover, levels of the second messenger, inositol triphosphate (IP3), were significantly delayed in chlordane-treated animals following interaction with IFN/LPS. When nitrate/nitrite production was analyzed as an alternate mechanism for killing tumors, stimulated m phi from both normal and chlordane-treated animals responded equally. The data show that chlordane differentially introduces defects in m phi biochemical mechanisms associated with tumor killing.

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References

    1. J Immunol. 1984 Apr;132(4):1980-6 - PubMed
    1. J Immunol. 1986 Oct 15;137(8):2585-91 - PubMed
    1. J Clin Invest. 1977 Dec;60(6):1266-79 - PubMed
    1. Fundam Appl Toxicol. 1990 May;14(4):688-95 - PubMed
    1. Immunol Today. 1987;8(5):151-8 - PubMed

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