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. 2003 Nov;185(21):6490-2.
doi: 10.1128/JB.185.21.6490-6492.2003.

Host range of chlamydiaphages phiCPAR39 and Chp3

J S Everson  1 , S A Garner, P R Lambden, B A Fane, I N Clarke
Affiliations

Host range of chlamydiaphages phiCPAR39 and Chp3

J S Everson et al. J Bacteriol. 2003 Nov.

Abstract

The host range of phiCPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that phiCPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.

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Figures

FIG. 1.
FIG. 1.
Binding of Chp3 and φCPAR39 with susceptible and nonsusceptible hosts. Shown are relative binding of C. felis EBs by Chp3 (column 1) and φCPAR39 (column 2) and the effects on such binding by Chp3 (column 3) and φCPAR39 (column 4) following treatment of EBs with proteinase K. Columns 5 to 8 show relative binding to C. pneumoniae EBs by Chp3 (column 5) and φCPAR39 (column 6) and the effects on such binding by Chp3 (column 7) and φCPAR39 (column 8) following treatment of EBs with proteinase K.
See this image and copyright information in PMC

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