doi: 10.1081/NCN-120022688.
Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives
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- PMID: 14565314
- DOI: 10.1081/NCN-120022688
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Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives
Nucleosides Nucleotides Nucleic Acids.
2003 May-Aug.
Abstract
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.
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