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. 2003 May-Aug;22(5-8):931-3.
doi: 10.1081/NCN-120022688.

Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives

G Luoni  1 , C McGuigan, G Andrei, R Snoeck, E De Clercq, J Balzarini
Affiliations

Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives

G Luoni et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug.

Abstract

We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.

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