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. 2003 May-Aug;22(5-8):1263-5.
doi: 10.1081/NCN-120022942.

Imidazolethyl-phosphoramidate alpha-oligonucleotides

T Michel  1 , L Mouls, F Debart, J J Vasseur
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Imidazolethyl-phosphoramidate alpha-oligonucleotides

T Michel et al. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug.

Abstract

Alpha-ODNs conjugated to imidazole groups via phosphoramidate internucleosidic linkages were synthesized. The presence of the imidazolethyl-phosphoramidate linkage improved the affinity of alpha-ODNs for their nucleic acid targets.

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