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. 2003 Oct 30;92(3):227-31.
doi: 10.1016/s0168-3659(03)00372-9.

Biodegradable electrospun fibers for drug delivery

Jing Zeng  1 , Xiaoyi Xu, Xuesi Chen, Qizhi Liang, Xinchao Bian, Lixin Yang, Xiabin Jing
Affiliations

Biodegradable electrospun fibers for drug delivery

Jing Zeng et al. J Control Release. .

Abstract

The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future.

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