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Review
. 2003 Oct;3(10):756-67.
doi: 10.1038/nrc1186.

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Freddy Radtke  1 , Kenneth Raj
Affiliations
Review

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Freddy Radtke et al. Nat Rev Cancer. 2003 Oct.

Abstract

Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.

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