Beat-to-beat repolarisation variability in body surface electrocardiograms

Abstract

The repolarisation variability in body surface electrocardiograms has been evaluated by beat-to-beat QT interval variability. Interpolated R-peak time and template T-wave matching algorithms were used to determine the characteristic time points of the R-wave and T-wave, respectively. The T-wave time can be determined accurately and robustly by searching for the best match between a template T-wave and measured T-waves. The authors studied 5 min multichannel ECG recordings (35 channels) measured in 20 healthy subjects. A QT variability of 2.24 +/- 0.79 ms was obtained (1.15 +/- 0.30 ms, if linear detrend was used), which is significantly lower than that reported in several other studies. To explore this discrepancy, the sensitivity of the template matching algorithm to periodic and random noise on the ECG was estimated by a simulation study. The results showed that the repolarisation variability depended on selection of the appropriate lead, the signal-to-noise ratio and the effectiveness of baseline correction. Lead II of a standard 12-lead ECG is a reasonable choice for QT variability analysis; however, precordial leads V3-V6 could be better with regard to the amplitude of the T-wave. Poor signal-to-noise ratios can lead to unrealistic values for repolarisation variability.