Review
doi: 10.1080/07853890310014605.
Cell cycle control, DNA damage checkpoints and cancer
Affiliations
- PMID: 14572162
- DOI: 10.1080/07853890310014605
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Review
Cell cycle control, DNA damage checkpoints and cancer
Ann Med.
2003.
Abstract
DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.
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