doi: 10.1021/ol0356338.
A new beta-carbolinone synthesis using a Rh(II)-promoted [3 + 2]-cycloaddition and Pd(0) cross-coupling/Heck cyclization chemistry
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- PMID: 14572283
- DOI: 10.1021/ol0356338
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A new beta-carbolinone synthesis using a Rh(II)-promoted [3 + 2]-cycloaddition and Pd(0) cross-coupling/Heck cyclization chemistry
Org Lett.
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Abstract
[reaction: see text]. A short and efficient synthesis of the beta-carbolinone ring system was achieved using a rhodium(II)-catalyzed [3 + 2]-cycloaddition, a Pd(0)-catalyzed C-N amination reaction, and a subsequent intramolecular Heck reaction as the key synthetic steps.
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