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. 2003 Nov;71(11):6658-63.
doi: 10.1128/IAI.71.11.6658-6663.2003.

Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection

Stanley M Spinola  1 , Cliffton T H Bong, Andrew L Faber, Kate R Fortney, Stacy L Bennett, Carisa A Townsend, Beth E Zwickl, Steven D Billings, Tricia L Humphreys, Margaret E Bauer, Barry P Katz
Affiliations

Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection

Stanley M Spinola et al. Infect Immun. 2003 Nov.

Abstract

With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.

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Figures

FIG. 1.
FIG. 1.
Percentages of PMNs and macrophages isolated from double-pustule formers (black bars) and double resolvers (open bars) that took up bacteria under opsonized and nonopsonized conditions. Results are expressed as the mean and SD for each group. Hd, strain 35000HP/pRB157K; Y, YPIII strain 582; Y−, YPIII strain 756, which was cured of plasmid pYV.
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