doi: 10.1007/BF00306025.
Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram
- PMID: 145745
- DOI: 10.1007/BF00306025
Item in Clipboard
Inhibition of diethylnitrosamine-induced strand breaks in liver DNA by disulfiram
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol.
1977 Oct.
Abstract
Disulfiram (DSF) delayed the appearance of diethylnitrosamine (DEN)-induced strand breaks in liver DNA of rats. The fragmentation of liver DNA produced by DEN was studied 4 and 24 h after administration of the carcinogen on alkaline sucrose gradients. A single dose of 500 mg/kg DSF given 1 h prior to carcinogen treatment delayed for at least 4 h the DEN--induced strand breaks in liver DNA. A single DSF pretreatment, however, did not protect against carcinogen-induced strand breaks when observed 24 h after DEN injection. It is possible that continuous administration of DSF might inhibit the DEN-produced damage of the genetic material.
Similar articles
-
Persistence and accumulation of (potential) single strand breaks in liver DNA of rats treated with diethylnitrosamine or dimethylnitrosamine: correlation with hepatocarcinogenicity.Chem Biol Interact. 1979 May;25(2-3):229-42. doi: 10.1016/0009-2797(79)90048-6. Chem Biol Interact. 1979. PMID: 466734
-
In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine.Chem Biol Interact. 1977 Oct;19(1):111-24. doi: 10.1016/0009-2797(77)90046-1. Chem Biol Interact. 1977. PMID: 411580
-
Differential induction of DNA strand breaks by nitrosamines in the rat liver and esophagus.Cancer Lett. 1988 Jun 15;40(2):203-11. doi: 10.1016/0304-3835(88)90012-2. Cancer Lett. 1988. PMID: 3383179
-
Influence of disulfiram on the metabolism of N-nitrosodiethylamine.IARC Sci Publ. 1984;(57):519-23. IARC Sci Publ. 1984. PMID: 6533043
-
Inhibition of diethylnitrosamine-induced rat liver chromosomal aberrations and DNA-strand breaks by synergistic supplementation of vanadium and 1alpha,25-dihydroxyvitamin D(3).Biochim Biophys Acta. 2000 Oct 18;1502(2):273-82. doi: 10.1016/s0925-4439(00)00053-3. Biochim Biophys Acta. 2000. PMID: 11040452
Cited by
-
Proline dithiocarbamate inhibits N-nitrosodiethylamine induced liver carcinogenesis.J Cancer Res Clin Oncol. 1992;118(6):401-4. doi: 10.1007/BF01629420. J Cancer Res Clin Oncol. 1992. PMID: 1377694 Free PMC article.
-
The sequential analysis of liver cell necrosis: inhibition of diethylnitrosamine- and dimethylnitrosamine-induced acute liver cell death by posttreatment with diethyldithiocarbamate.Am J Pathol. 1980 Apr;99(1):159-74. Am J Pathol. 1980. PMID: 6244740 Free PMC article.
-
Influence of a prolonged treatment with disulfiram and D-penicillamine on nitrosodiethylamine-induced biological and biochemical effects. II. Investigations on trace elements in the liver.J Cancer Res Clin Oncol. 1985;109(1):16-22. doi: 10.1007/BF01884249. J Cancer Res Clin Oncol. 1985. PMID: 3972881 Free PMC article.
-
Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.J Cancer Res Clin Oncol. 1980;97(2):209-12. doi: 10.1007/BF00409908. J Cancer Res Clin Oncol. 1980. PMID: 7462300 Free PMC article.
-
Effects of disulfiram on the metabolism of nitrosodiethylamine during liver carcinogenesis.J Cancer Res Clin Oncol. 1984;108(3):281-5. doi: 10.1007/BF00390458. J Cancer Res Clin Oncol. 1984. PMID: 6210292 Free PMC article.