Review
doi: 10.1097/00001622-199212000-00012.
Cisplatin and platinum analogues: recent advances
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- PMID: 1457521
- DOI: 10.1097/00001622-199212000-00012
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Review
Cisplatin and platinum analogues: recent advances
Curr Opin Oncol.
1992 Dec.
Abstract
Cisplatin is a critically important antineoplastic agent employed in treating patients who have a broad spectrum of neoplasms. Resistance to this agent poses a serious clinical dilemma. The objective of this review is to summarize the principal mechanisms that contribute to cytotoxicity by this agent and underlie resistance. Knowledge of these processes provides a rational basis for developing therapeutic strategies to circumvent resistance.
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