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Review
. 1992 Dec;4(6):1073-9.
doi: 10.1097/00001622-199212000-00012.

Cisplatin and platinum analogues: recent advances

R J Fram  1
Affiliations
Review

Cisplatin and platinum analogues: recent advances

R J Fram. Curr Opin Oncol. 1992 Dec.

Abstract

Cisplatin is a critically important antineoplastic agent employed in treating patients who have a broad spectrum of neoplasms. Resistance to this agent poses a serious clinical dilemma. The objective of this review is to summarize the principal mechanisms that contribute to cytotoxicity by this agent and underlie resistance. Knowledge of these processes provides a rational basis for developing therapeutic strategies to circumvent resistance.

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