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Review
. 2003;2(4):26.
doi: 10.1186/1475-4924-2-26. Epub 2003 Oct 22.

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis  1
Affiliations
Review

At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation

John M Kyriakis. J Biol. 2003.

Abstract

The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.

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Figure 1
Figure 1
Regulation of AMPK. AMPK (blue) becomes activated under conditions of high AMP/ATP (metabolic depletion), or in response to the hormones leptin and adiponectin [1,25,26]. Under these circumstances, AMP binds to AMPK, facilitating phosphorylation at Thr172 and activation, in a reaction catalyzed by the LKB1-STRAD-MO25 complex (AMPKK; red). AMP also prevents dephosphorylation and deactivation of AMPK and serves as an allosteric activator of AMPK. See text for further details.
See this image and copyright information in PMC

References

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