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. 2003 Oct;143(1-2):120-3.
doi: 10.1016/j.jneuroim.2003.08.025.

A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis

Francesca Coraddu  1 , Marina Lai, Cristina Mancosu, Eleonora Cocco, Stephen Sawcer, Efrosini Setakis, Alastair Compston, Maria Giovanna Marrosu
Affiliations

A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis

Francesca Coraddu et al. J Neuroimmunol. 2003 Oct.

Abstract

Using indirect whole genome association screening, we have searched for multiple sclerosis susceptibility genes in the genetically isolated high risk Sardinian population. Two screens were performed; the first was based on 229 cases and 264 unrelated controls, and the second on 235 trio families. Each screen employed a dense set of microsatellite markers and DNA pooling. Data from both screens were available from 2764 markers. Nine markers showed nominally significant results in both screens independently. Five of these markers-D2S408 (2q36), D6S271 (6p21), D6S344 (6p25), D7S1818 (7p12) and D16S420 (16p12)-remained nominally significant in both studies after conservative refining analysis.

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