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. 2003 Nov;47(11):3630-3.
doi: 10.1128/AAC.47.11.3630-3633.2003.

Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines

Teresa Krakauer  1 , Marilyn Buckley
Affiliations

Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines

Teresa Krakauer et al. Antimicrob Agents Chemother. 2003 Nov.

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

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Figures

FIG. 1.
FIG. 1.
Dose-response inhibition of IL-1β and IL-6 (A), TNF-α and IFN-γ (B), and MCP-1, MIP-1α, and MIP-1β (C) production by PBMC stimulated with 200 ng of SEB per ml in the presence of various concentrations of doxycycline. Values represent the mean ± SD of duplicate samples from three experiments.
FIG. 2.
FIG. 2.
Inhibition of IL-1β, IL-6, TNF-α, and IFN-γ (A) and MCP-1, MIP-1α, and MIP-1β (B) production by PBMC stimulated with SEB (200 ng/ml) or TSST-1 (200 ng/ml) in the presence of 0.05 mM doxycycline (Dox). Values represent the mean ± SD of PBMC cultures from seven blood donors. Results are statistically significantly different (P < 0.05) between SE and SE-plus-doxycycline samples.
FIG. 3.
FIG. 3.
Inhibition of T-cell proliferation in PBMC stimulated with 200 ng of SEB or TSST-1 per ml by various concentrations of doxycycline. Values are the mean count ± the standard error of the mean of triplicate cultures and represent five experiments. Results are statistically significantly different (P < 0.02) between SE and SE-plus-doxycycline samples.
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References

    1. Baker, M. D., and K. A. Acharya. 2003. Superantigens: structure, function, and diversity, p. 1-31. In T. Krakauer (ed.), Superantigen protocols. Humana Press, Totowa, N.J. - PubMed
    1. Bergdoll, M. S., and P. M. Schlievert. 1984. Toxic shock syndrome toxin. Lancet ii:691.
    1. Boyle, J. R., E. McDermott, M. Crowther, A. D. Wills, P. R. Bell, and M. M. Thompson. 1998. Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurismal disease. J. Vasc. Surg. 27:354-361. - PubMed
    1. Cameron, S. B., M. C. Nawijn, W. W. Kum, H. F. Savelkoul, and A. W. Chow. 2001. Regulation of helper T cell responses to staphylococcal superantigens. Eur. Cytokine Netw. 12:210-222. - PubMed
    1. Chatila, T., and R. S. Geha. 1993. Signal transduction of microbial superantigens via MHC class II molecules. Immunol. Rev. 131:43-59. - PubMed

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