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. 2003 Nov;47(11):3672-3.
doi: 10.1128/AAC.47.11.3672-3673.2003.

Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan

Tsi-Shu Huang  1 , Susan Shin-Jung Lee, Hui-Zin Tu, Wen-Kuei Huang, Yao-Shen Chen, Chung-Kai Huang, Shue-Ren Wann, Hsi-Hsun Lin, Yung-Ching Liu
Affiliations

Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan

Tsi-Shu Huang et al. Antimicrob Agents Chemother. 2003 Nov.

Abstract

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

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References

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