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Clinical Trial
. 1992 Oct 15;32(8):705-11.
doi: 10.1016/0006-3223(92)90300-o.

Melatonin and jet lag: confirmatory result using a simplified protocol

B Claustrat  1 , J Brun, M David, G Sassolas, G Chazot
Affiliations
Clinical Trial

Melatonin and jet lag: confirmatory result using a simplified protocol

B Claustrat et al. Biol Psychiatry. .

Abstract

This study replicates the alleviation of jet-lag with melatonin in a simplified protocol for eastward flight. At 22-n hr (n is the time-lag between the North American departure point and France), subjects took either melatonin (8 mg, n = 15), or placebo (n = 15) on the day of the return flight and for 3 consecutive days. On day 8, self-ratings significantly discriminated between melatonin and placebo for global treatment efficacy, morning fatigue, and evening sleepiness.

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Comment in

  • Melatonin and jet lag: treatment schedule.
    Lino A, Silvy S, Condorelli L, Rusconi AC. Lino A, et al. Biol Psychiatry. 1993 Oct 15;34(8):587. doi: 10.1016/0006-3223(93)90208-u. Biol Psychiatry. 1993. PMID: 8274592 No abstract available.

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