[Analysis of the nasal complication after radiotherapy in patients with nasopharyngeal carcinoma by logistic regression]

Abstract

Objective: To study of the risk factors of the nasal complication after radiotherapy in patients with nasopharyngeal carcinoma(NPC).

Method: Observed 131 cases nasal disease in NPC patients, analyzed the factors that might cause the complication by using Logistic regression model.

Result: The highest incidences of complication after radiotherapy was chronic purulent sinusitis (116/131), the chosen factors in the regression formula were T staging and radiation for anterior field of the nose. The second was nasal synechia(33/131), the chosen factors were total dose of external irradiation, intracavitary irradiation and medicamentous rhinitis. The incidences of atrophic rhinitis was the lowest (9/131), the chosen factors were chemotherapy and medicamentous rhinitis.

Conclusion: T staging of tumor and radiation for anterior field of the nose had relation with post radiotherapy sinusitis. It was easy to lead to nasal synechia when the does of external irradiation being higher or adding intracavitary irradiation or using the decongestant for long time. Chemotherapeutic drugs and decongestant may be the risk factors of atrophic rhinitis.