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Clinical Trial
. 2003 Oct:250 Suppl 3:III44-6.
doi: 10.1007/s00415-003-1308-5.

Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

Curt R Freed  1 , Maureen A Leehey, Michael Zawada, Kimberly Bjugstad, Laetitia Thompson, Robert E Breeze
Affiliations
Clinical Trial

Do patients with Parkinson's disease benefit from embryonic dopamine cell transplantation?

Curt R Freed et al. J Neurol. 2003 Oct.

Abstract

Embryonic dopamine cell transplants survive in nearly all patients regardless of age and without immunosuppression. Transplants can improve Parkinson "off" symptoms up to the best effects of L-dopa observed preoperatively. They cannot improve the "best on" state. Transplants appear to survive indefinitely. In 10 to 15% of patients, transplants can reproduce the dyskinetic effects of L-dopa even after discontinuing all L-dopa. Neurotransplantation should be tried earlier in the clinical course of Parkinson's to see if earlier intervention can prevent progression of the disease, particularly the dyskinetic responses seen after longterm L-dopa treatment.

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