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Review
. 2003 Oct;12(4):799-800.
doi: 10.1016/s1097-2765(03)00403-9.

Better late than never for repair of miscoding lesions within a transcribed template

Erling Seeberg  1 , Arne Klungland
Affiliations
Free article
Review

Better late than never for repair of miscoding lesions within a transcribed template

Erling Seeberg et al. Mol Cell. 2003 Oct.
Free article

Abstract

Transcription does not always stall at base damage in DNA and can create mutated transcripts from miscoding lesions. In this issue of Molecular Cell, present genetic analysis of E. coli to indicate that the highly mutagenic purine modification, 8-oxoguanine, is subject to transcription-coupled repair despite transcriptional bypass and generation of mutant transcripts.

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