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Review
. 2003 Oct;14(5):475-83.
doi: 10.1016/j.copbio.2003.09.002.

Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates

Ilana S Aldor  1 , Jay D Keasling
Affiliations
Review

Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates

Ilana S Aldor et al. Curr Opin Biotechnol. 2003 Oct.

Abstract

Implementing several metabolic engineering strategies, either individually or in combination, it is possible to construct microbial plastic factories to produce a variety of polyhydroxyalkanoate (PHA) biopolymers with desirable structures and material properties. Approaches include external substrate manipulation, inhibitor addition, recombinant gene expression, host cell genome manipulation and, most recently, protein engineering of PHA biosynthetic enzymes. In addition, mathematical models and molecular methods can be used to elucidate metabolically engineered systems and to identify targets for performance improvement.

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