A patient with epilepsia partialis continua with anti-glutamate receptor epsilon 2 antibodies

Abstract

This report concerns a 6-year-old female with epilepsia partialis continua. Autoantibodies against amino- and carboxyl-terminal regions of the N-methyl-D-aspartate receptor subunit glutamate receptor epsilon 2 were detected in the serum and cerebrospinal fluid. The anti-glutamate receptor epsilon 2 subunit antibodies have been demonstrated in the serum and cerebrospinal fluid in some patients with chronic progressive epilepsia partialis continua of childhood and those with Rasmussen's encephalitis. The patient, however, did not develop any neurologic deterioration or intractable seizures. Therefore, anti-glutamate receptor epsilon 2 subunit antibodies are not specific for chronic progressive epilepsia partialis continua of childhood and Rasmussen's encephalitis.