Comparative Study
[The experimental treatment of cyanide poisoning with a methemoglobin solution]
[Article in
Russian]
- PMID: 1458169
Item in Clipboard
Comparative Study
[The experimental treatment of cyanide poisoning with a methemoglobin solution]
[Article in
Russian]
Eksp Klin Farmakol.
1992 May-Jun.
Abstract
The stroma-free methemoglobin solution proved to be an effective antidote against acute cyanide poisoning in experiment. The poisoning was induced by intraperitoneal administration to rats of cyanide solutions in doses of 5, 10 and 15 mg/kg. Methemoglobin solutions were injected intravenously in doses of 2 and 4 g/kg. All the rats given methemoglobin solution after the administration of cyanide survived. Spectrophotometry of rat urine demonstrated rapid excretion of methemoglobin cyanide.
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