Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
- PMID: 1458460
Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention
Abstract
Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with Helicobacter pylori. The intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. The final stages have been linked with the supply of beta-carotene and with excessive salt intake. Nitrosating agents are candidate carcinogens and could originate in the gastric cavity or in the inflammatory infiltrate.
Comment in
-
The war of the worlds: metaplastic versus nonmetaplastic atrophic gastritis.Gastrointest Endosc. 2011 Feb;73(2):411-2; author reply 412-3. doi: 10.1016/j.gie.2010.06.030. Gastrointest Endosc. 2011. PMID: 21295657 No abstract available.
Similar articles
-
Chronic gastritis, intestinal metaplasia, dysplasia and Helicobacter pylori in gastric cancer: putting the pieces together.Ital J Gastroenterol. 1994 Dec;26(9):449-58. Ital J Gastroenterol. 1994. PMID: 7599347 Review.
-
Antral-type mucosa in the gastric incisura, body, and fundus (antralization): a link between Helicobacter pylori infection and intestinal metaplasia?Am J Gastroenterol. 2000 Jan;95(1):114-21. doi: 10.1111/j.1572-0241.2000.01609.x. Am J Gastroenterol. 2000. PMID: 10638568
-
The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection.Helicobacter. 2007 Feb;12(1):1-15. doi: 10.1111/j.1523-5378.2007.00475.x. Helicobacter. 2007. PMID: 17241295 Review.
-
Helicobacter pylori infection in gastric cancerogenesis.J Physiol Pharmacol. 2009 Sep;60(3):3-21. J Physiol Pharmacol. 2009. PMID: 19826177 Review.
-
Role of Helicobacter pylori gastritis in gastric atrophy, intestinal metaplasia, and gastric neoplasia.Microsc Res Tech. 2000 Mar 15;48(6):313-20. doi: 10.1002/(SICI)1097-0029(20000315)48:6<313::AID-JEMT1>3.0.CO;2-Y. Microsc Res Tech. 2000. PMID: 10738312 Review.
Cited by
-
The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea.Gut Liver. 2012 Jul;6(3):321-7. doi: 10.5009/gnl.2012.6.3.321. Epub 2012 May 22. Gut Liver. 2012. PMID: 22844559 Free PMC article.
-
Increased Proliferative Activity Accompanies the Local Inflammatory Response of Gastric Mucosa After Intragastric Balloon Insertion.Dig Dis Sci. 2016 Dec;61(12):3498-3505. doi: 10.1007/s10620-016-4344-6. Epub 2016 Oct 14. Dig Dis Sci. 2016. PMID: 27743165
-
Operative link for gastritis assessment vs operative link on intestinal metaplasia assessment.World J Gastroenterol. 2011 Nov 7;17(41):4596-601. doi: 10.3748/wjg.v17.i41.4596. World J Gastroenterol. 2011. PMID: 22147965 Free PMC article.
-
Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model.Nutrients. 2015 Jan 6;7(1):306-20. doi: 10.3390/nu7010306. Nutrients. 2015. PMID: 25569625 Free PMC article.
-
Osteopontin depletion decreases inflammation and gastric epithelial proliferation during Helicobacter pylori infection in mice.Lab Invest. 2015 Jun;95(6):660-71. doi: 10.1038/labinvest.2015.47. Epub 2015 Apr 13. Lab Invest. 2015. PMID: 25867766
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Other Literature Sources
Medical