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. 1992;31(1):76-8.
doi: 10.1007/BF00695998.

Serum elimination half-life of tamoxifen and its metabolites in patients with advanced breast cancer

D de Vos  1 , P H Slee, D Stevenson, R J Briggs
Affiliations

Serum elimination half-life of tamoxifen and its metabolites in patients with advanced breast cancer

D de Vos et al. Cancer Chemother Pharmacol. 1992.

Abstract

In breast cancer patients discontinuing chronic tamoxifen therapy, the serum elimination of metabolites X, Y and E paralleled that of tamoxifen, whereas that of metabolite Z did not. The serum elimination of tamoxifen and metabolites X and B was increased by amino-glutethimide treatment, whereas that of metabolites Z, Y, and E was not.

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