Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Nov;35(3):213-4.
doi: 10.1038/ng1252.

Maintenance of heterochromatin by RNA interference of tandem repeats

Robert A Martienssen  1
Affiliations

Maintenance of heterochromatin by RNA interference of tandem repeats

Robert A Martienssen. Nat Genet. 2003 Nov.

Abstract

Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.

PubMed Disclaimer

MeSH terms

Substances

LinkOut - more resources