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Review
. 2004 Feb;63(5):510-9.
doi: 10.1007/s00253-003-1431-3. Epub 2003 Oct 31.

Lincomycin, cultivation of producing strains and biosynthesis

Affiliations
Review

Lincomycin, cultivation of producing strains and biosynthesis

J Spízek et al. Appl Microbiol Biotechnol. 2004 Feb.

Abstract

Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice. The chemical structure of lincosamide antibiotics, cultivation of producing strains and analytical procedures used for separation and isolation of these compounds are described in this review. Biosynthesis of lincomycin and related compounds and its genetic control are briefly discussed.

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