Lincomycin, cultivation of producing strains and biosynthesis
- PMID: 14593504
- DOI: 10.1007/s00253-003-1431-3
Lincomycin, cultivation of producing strains and biosynthesis
Abstract
Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice. The chemical structure of lincosamide antibiotics, cultivation of producing strains and analytical procedures used for separation and isolation of these compounds are described in this review. Biosynthesis of lincomycin and related compounds and its genetic control are briefly discussed.
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