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. 1992 Nov 1;77(1-3):109-15.
doi: 10.1016/0378-1097(92)90140-j.

Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium

N E Allen  1 , J N Hobbs Jr, J M Richardson, R M Riggin
Affiliations

Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium

N E Allen et al. FEMS Microbiol Lett. .

Abstract

In the presence of bacitracin, vancomycin-resistant Enterococcus faecium (vanA phenotype) accumulate UDP-N-acetylmuramyl(UDP-Mur-NAc)-tetrapeptide and a UDP-MurNAc-depsipentapeptide containing lactate substituted for the carboxy-terminal-D-alanine residue. In an in vitro peptidoglycan polymerization assay, the modified precursors function and confer resistance to vancomycin.

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