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. 2003 Nov;89(11):1316-21.
doi: 10.1136/heart.89.11.1316.

Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography

A Ionescu  1 , A G Fraser, E G Butchart
Affiliations

Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography

A Ionescu et al. Heart. 2003 Nov.

Abstract

Objective: To assess the prevalence, mechanisms, and significance of paraprosthetic regurgitation detected incidentally by transoesophageal echocardiography (TOE) in patients after heart valve replacement.

Design: Prospective observational study.

Setting: Tertiary referral centre.

Patients: 360 consecutive patients (mean (SD) age 65.8(9.5) years, 193 women) undergoing elective first ever valve replacement.

Methods: Postoperative and follow up TOE, and tests for haemolysis and anaemia.

Results: There were 243 aortic, 90 mitral, and 27 double valve replacements, using 316 mechanical and 44 tissue valves, giving 270 aortic and 117 mitral valves. One patient with severe paraprosthetic mitral regurgitation underwent immediate reoperation and was excluded from subsequent analyses. Paraprosthetic jets were detected around 16 (6%) of the aortic and 38 (32%) of the mitral valves (p < 0.05) at the postoperative study. Follow up TOE was available for 151 aortic and 67 mitral valves, 0.9 (0.5) years after operation. Paraprosthetic jets were present in 15 (10%) of the aortic and 10 (15%) of the mitral valves (NS). Two thirds of the aortic and a fifth of the mitral jets were new. Paraprosthetic jets were more common in aortic valves in a supra-annular (12 of 88, 14%) than in an intra-annular position (4 or 182, 2%; p < 0.005) and in mitral valves inserted with continuous (36 of 88, 41%) rather than interrupted sutures (2 of 28, 7%; p < 0.001). Lactate dehydrogenase concentration was higher in patients with paraprosthetic jets than in those without (752 (236) v 654 (208) IU/l, p < 0.001). Haemoglobin and haptoglobin concentrations were not different.

Conclusions: Small paraprosthetic leaks are common, are related to surgical factors, are not associated with increased subclinical haemolysis, and are benign during the first year after heart valve replacement.

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Figures

Figure 1
Figure 1
Prevalence and course of incidental paraprosthetic regurgitation. AVR, aortic valve replacement; MVR, mitral valve replacement; N/A, not available; PJ, paraprosthetic jet; TOE, transoesophageal echocardiogram.
See this image and copyright information in PMC

References

    1. Kloster FE. Diagnosis and management of complications of prosthetic heart valves. Am J Cardiol 1975;35:872–5. - PubMed
    1. Shunei K, Shinichi T, Matsumura M, et al. Immediate and early postoperative evaluation of results of cardiac surgery by transesophageal two-dimensional Doppler echocardiography. Circulation 1987;76(suppl V):113–21. - PubMed
    1. Kapur KK, Fan P, Nanda NC, et al. Doppler color flow mapping in the evaluation of prosthetic mitral and aortic valve function. J Am Coll Cardiol 1989;13:1561–71. - PubMed
    1. Chambers J, Monaghan M, Jackson G. Colour flow Doppler mapping in the assessment of prosthetic valve regurgitation. Br Heart J 1989;62:1–8. - PMC - PubMed
    1. Glisenti F, Ghiringhelli S, Straneo U, et al. Intra- and paraprosthetic valve regurgitation. A color Doppler echocardiographic study. Acta Cardiologica 1991;46:121–7. - PubMed

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