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. 2003 Oct;19(10):1413-6.
doi: 10.2116/analsci.19.1413.

Analysis of lead in tooth enamel by laser ablation-inductively coupled plasma-mass spectrometry

Tsutomu Uryu  1 , Jun Yoshinaga, Yukio Yanagisawa, Masahiko Endo, Junichi Takahashi
Affiliations
Free article

Analysis of lead in tooth enamel by laser ablation-inductively coupled plasma-mass spectrometry

Tsutomu Uryu et al. Anal Sci. 2003 Oct.
Free article

Abstract

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to determine the Pb/Ca ratios in the enamel of deciduous incisors, a biomarker of in utero Pb exposure, using pelletized bone certified reference materials (CRMs) as calibrants. The detection limit for Pb by LA-ICP-MS was 11 microg kg(-1) demonstrating an adequate sensitivity for Pb in the teeth of unexposed individuals (0.1-10 mg kg(-1)). The precision for the Pb/Ca ratios in NIST SRM 1486 Bone Meal was 3.4%. The correlation between Pb/Ca ratios obtained by LA-ICP-MS and those obtained by a digestion method was highly significant. We found one point calibration by a CRM was applicable for the quantification of Pb in tooth enamel. This method will be valuable for the assessment of in utero Pb exposure levels.

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