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Comment
. 2003 Nov 3;198(9):1285-8.
doi: 10.1084/jem.20031664.

Sulfated sugars for rolling lymphocytes

Klaus Ley  1
Affiliations
Comment

Sulfated sugars for rolling lymphocytes

Klaus Ley. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Lymphocyte rolling in high endothelial venules in WT and HEC-GlcNAc6ST−/− mice. (Left) In WT mice, L-selectin on a lymphocyte engages a class 1–sulfated ligand, which supports rolling and causes L-selectin–dependent signal transduction. Class 2 L-selectin ligands are expressed but are probably of little relevance in WT mice. Sulfated proteoglycans present CCL21 to its receptor, CCR7, leading to additional activating signals. The integration of L-selectin and CCR7 signals result in increased LFA-1 affinity, which allows binding to ICAM-1, causing lymphocyte arrest. (Right) In HEC-GlcNAc6ST−/− mice, class 1 L-selectin ligands are undersulfated and not functional. Class 2 L-selectin ligands, which are overexpressed, engage L-selectin but do not cause L-selectin–dependent cell and integrin activation. Alternatively, or in addition, proteoglycans may be undersulfated and fail to immobilize CCL21 effectively, preventing or diminishing CCR7-dependent activation. As a result, LFA-1 is not activated and does not engage ICAM-1, and the cell keeps rolling.
See this image and copyright information in PMC

Comment on

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