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. 2003 Sep;69(9):864-6.
doi: 10.1055/s-2003-43204.

A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

Russell B Williams  1 , Jeannine Hoch, Thomas E Glass, Randy Evans, James S Miller, Jan H Wisse, David G Kingston
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A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest

Russell B Williams et al. Planta Med. 2003 Sep.

Erratum in

  • Planta Med. 2005 Apr;71(4):354

Abstract

Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC (50) values of 6.8 and 8.0 microg/mL, respectively.

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