Review
doi: 10.1002/ijc.11487.
The IGF-1 receptor in cancer biology
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- PMID: 14601044
- DOI: 10.1002/ijc.11487
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Review
The IGF-1 receptor in cancer biology
Int J Cancer.
.
Abstract
The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.
Copyright 2003 Wiley-Liss, Inc.
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