Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Dec 20;107(6):873-7.
doi: 10.1002/ijc.11487.

The IGF-1 receptor in cancer biology

Renato Baserga  1 , Francesca Peruzzi, Krysztof Reiss
Affiliations
Review

The IGF-1 receptor in cancer biology

Renato Baserga et al. Int J Cancer. .

Abstract

The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

PubMed Disclaimer

Publication types

LinkOut - more resources